Vaping increases risk of DNA mutations which could lead to cancer, study suggests

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Vaping could increase the risk of mouth cancers, according to a new study, which suggests e-cigarettes lead to the buildup of chemicals known to cause harmful DNA mutations.

US researchers presented findings from a small as yet unpublished trial which showed that after a 15-minute vaping session, three chemicals known to be carcinogens increased measurably in the saliva.

Most of the trial participants also showed signs of DNA damage caused by one of the chemicals, acrolein, which is produced when glycerol – a common vape fluid ingredient – breaks down in heat.

E-cigarettes remain substantially safer than conventional cigarettes because they do not contain the host of poisonous substances found in tobacco leaf that coat the throat, mouth and lungs in tar.

However, the researchers said there may be long-term health effects that need to be understood given their increasing popularity.

“Comparing e-cigarettes and tobacco cigarettes is really like comparing apples and oranges. The exposures are completely different,” said Dr Silvia Balbo, from Masonic Cancer Centre in Minnesota, who led the research.

“We still don’t know exactly what these e-cigarette devices are doing and what kinds of effects they may have on health, but our findings suggest that a closer look is warranted.”

For the research they recruited five volunteers and looked at the cancer-causing chemicals that built up after vaping, as well as analysing the type of DNA damage they caused.

They found three chemicals build up in the mouth after vaping – formaldehyde, acrolein, and methylglyoxal – all of which are known to cause DNA mutations, but there is little information on their effect in combination, Dr Balbo said.

When analysing the effect of these chemicals on the cells in the mouth, they found four out of five volunteers had measurable DNA damage. They saw measurable “DNA adducts” which are caused when chemicals like acrolein react with cellular DNA – if the cell is unable to repair the damage or if mutations build up over time, this could lead to cancer.

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